Greatest Medication is returning for season 2 on Fox — however is each solid member coming again to the present?
The present follows a health care provider who strikes from Boston to a small apply within the East Coast fishing village the place he vacationed as a toddler. Along with Josh Charles, the solid consists of Josh Segarra, Abigail Spencer, Cree Cicchino, Annie Potts, Didi Conn, Clea Lewis, Stephen Spinella, Jason Veasey, Cindy De La Cruz, John DiMaggio, Carter Shimp and canine Wattson.
“The best way that [executive producer] Liz Tuccillo has structured the present, each episode we’ve an important star come on they usually get to do one thing pleasant — and perhaps one thing you’ve by no means seen them do earlier than,” Spencer solely instructed Us in January 2026. “I’d say what I notably liked concerning the present was that it’s a nice alternative for a few of our extra seasoned actors locally.”
She continued: “There’s a whole lot of roles throughout ages the place I’m like, ‘God, we may get so many nice actors to return.’ I liked that.”
Maintain scrolling to see who’s and isn’t coming again on Greatest Medication:
Josh Charles
There can be no Greatest Medication with out Charles’ efficiency as Martin Greatest.
Abigail Spencer
Spencer is entrance and heart in season 2 of the hit medical drama.
Josh Segarra
Segarra, who performs Mark Mylow, is again within the function of the city’s sheriff and Louisa’s ex-fiancé.
Cree
Elaine’s journey continues in season 2 of Greatest Medication.
Annie Potts
Potts will proceed enjoying Aunt Sarah a.ok.a Dr. Greatest’s aunt and the native lobster lady.
Stephen Spinella
Spinella was promoted for season 2 after introducing Us to Greg.
Jason Veasey
Veasey’s function as George has additionally been expanded in season 2 of Greatest Medication.
Carter Shimp
Elaine’s love curiosity — Al — can be featured within the sophomore season.
Wattson
After being named Copernicus, the city’s stray canine is coming again in season 2 as Dr. Greatest’s pet.


